We have had Buick 455s w/reduction units run in excess of 4,000 hours, many of which were hard use - 1000# payload hours. These engines are built tight to begin with then well maintained. Max RPMs at 4200. Our biggest problems have been valve wear from running unleaded gas, and temperature.
Because of high temps we have had detonation tear a couple of engines apart. Due to this we have switched to larger, aluminum radiators. When we opened these engines up they show little cylinder or bearing wear and would have continued to run reliably till the valve seats died. The next engine we build up will have hard seats that were not available a few years ago.