We use MMO when running unleaded fuel in an engine that is known NOT to have hardened valve seats like an old 392 Hemi (unmolested) . Most importantly, keep the drums completely sealed or you will lose "light vapors" which is the easiest part of gasoline to evaporate and also where the octane comes from. That's why all the guys with bass boats who run last years' gas wipe out engines....no octane left in the old fuel. IMO oil in general in fuel is a bad thing. It causes detonation. I'm not sure why, but it does. You'ld think it'd make the fuel burn slower instead of pop ,but under heat and pressure, it won't. It explodes. We do use it or ATF in the oil in hydraulic cammed engines as the detergents keep lifters operating properly, especially on a "less than avg." serviced engine. Again, if the rings aren't very good, it also aids in detonation, since it gets by easier than regular motor oil. I will say too for anyone who runs a flat tappet automotive engine, don't use synthetic anything. May not hurt in the gas, but def. not in the oil, unless you are borderline on detonation anyway. Mineral base only. The reasoning behind this (and it came to me from the owner of Comp Cams) is that synthetic is too slick for flat tappets (regular lifters). The cams are ground so that the lifter rotates in the bore a tad every time you open the valve, giving an even wear pattern. Using syn. makes it so slick, the cam will no longer rotate the lifter and eventually wears a flat spot in it on one side and kills the cam. On a roller cam, by all means use synthetic and that's the only reason not to. It has superior oiling characteristics and on a molecular level, all the molecules are the exact same size, in mineral oil ,there are millions of different sizes, so the ball bearing effect isn't quite as good.